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Gastroenterology
Predictors for the need for endoscopic therapy in patients with presumed acute upper gastrointestinal bleeding
Su Sun Kim, Kyung Up Kim, Sung Jun Kim, Seung In Seo, Hyoung Su Kim, Myoung Kuk Jang, Hak Yang Kim, Woon Geon Shin
Korean J Intern Med. 2019;34(2):288-295. Published online December 15, 2017
Background/Aims: Selecting patients with an urgent need for endoscopic hemostasis is difficult based only on simple parameters of presumed acute upper gastrointestinal bleeding. This study assessed easily applicable factors to predict cases in need of urgent endoscopic hemostasis due to acute upper ..
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Rheumatology
Clinical outcomes and pathological characteristics of immunoglobulin G4-related ophthalmic disease versus orbital inflammatory pseudotumor
Hong Ki Min, Youn Soo Lee, Suk-Woo Yang, Jennifer Lee, Seung-Ki Kwok, Ji Hyeon Ju, Wan-Uk Kim, Sung-Hwan Park
Korean J Intern Med. 2019;34(1):220-226. Published online October 19, 2017
Background/Aims: This study investigated the clinical and pathological features of immunoglobulin G4 (IgG4)-related ophthalmic disease. To clarify the features, we compared IgG4-related ophthalmic disease and orbital inflammatory pseudotumor.
Methods: We retrospectively reviewed the medical records..
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Hemato-oncology
Factors associated with treatment interruption in elderly patients with cancer
Hye Sung Won, Der Sheng Sun, Ji Young Choi, Ho Jung An, Yoon Ho Ko
Korean J Intern Med. 2019;34(1):156-164. Published online February 23, 2018
Background/Aims: This study was conducted to identify risk factors that predict vulnerability to cancer therapy on the basis of the clinical, geriatric, and quality of life assessment before starting treatment in elderly patients.
Methods: Seventy-five patients aged 65 years and over with newly dia..
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Cardiology
Update on heart failure management and future directions
[corrected-article]
Hong-Mi Choi, Myung-Soo Park, Jong-Chan Youn
Korean J Intern Med. 2019;34(1):11-43. Published online December 28, 2018
Heart failure (HF) is an important cardiovascular disease because of its increasing prevalence, significant morbidity, high mortality, and rapidly expanding health care cost. The number of HF patients is increasing worldwide, and Korea is no exception. There have been marked advances in definition, ..
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Infectious diseases
Adverse drug reaction monitoring during antimicrobial therapy for septicemia patients at a university hospital in New Delhi
Muhammad Shamshir Alam, Krishna Kolappa Pillai, Syed Aliul Hasan Abdi, Prem Kapur, Paru Kutty Pillai, Kandasamy Nagarajan
Korean J Intern Med. 2018;33(6):1203-1209. Published online September 6, 2017
Background/Aims: Adverse drug reaction (ADR) is an appreciably harmful or unpleasant reaction, resulting from an intervention related to the use of a medicinal product. The present study was conducted in order to monitor the frequency and severity of ADR during antimicrobial therapy of septicemia.
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Hemato-oncology
No benefit of hypomethylating agents compared to supportive care for higher risk myelodysplastic syndrome
Sang Kyun Sohn, Joon Ho Moon, In Hee Lee, Jae Sook Ahn, Hyeoung Joon Kim, Joo Seop Chung, Ho Jin Shin, Sung Woo Park, Won Sik Lee, Sang Min Lee, Hawk Kim, Ho Sup Lee, Yang Soo Kim, Yoon Young Cho, Sung Hwa Bae, Ji Hyun Lee, Sung Hyun Kim, Ik Chan Song, Ji Hyun Kwon, Yoo Jin Lee
Korean J Intern Med. 2018;33(6):1194-1202. Published online December 15, 2017
Background/Aims: This study evaluated the role of hypomethylating agents (HMA) compared to best supportive care (BSC) for patients with high or very-high (H/VH) risk myelodysplastic syndrome (MDS) according to the Revised International Prognostic Scoring System.
Methods: A total of 279 H/VH risk MD..
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Clinical characteristics and treatment propensity in elderly patients aged over 80 years with colorectal cancer
Yun Hwa Jung, Jae Young Kim, Yu Na Jang, Sang Hoon Yoo, Gyo Hui Kim, Kang Min Lee, In Kyu Lee, Su Mi Chung, In Sook Woo
Korean J Intern Med. 2018;33(6):1182-1193. Published online November 24, 2017
Background/Aims: Elderly patients (≥ 80 years) with colorectal cancer (CRC) tend to avoid active treatment at the time of diagnosis despite of recent advances in treatment. The aim of this study was to determine treatment propensity of elderly patients aged ≥ 80 years with CRC in clinical practice ..
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Cardiology
Palliative and end-of-life care for heart failure patients in an aging society
Takahiro Okumura, Akinori Sawamura, Toyoaki Murohara
Korean J Intern Med. 2018;33(6):1039-1049. Published online May 23, 2018
The populations of Asian countries are expected to age rapidly in the near future, with a dramatic increase in the number of heart failure (HF) patients also anticipated. The need for palliative and end-of-life care for elderly patients with advanced HF is currently recognized in aging societies. Ho..
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Rheumatology
Clinical phenotypes of Korean patients with Behcet disease according to gender, age at onset,
and HLA-B51
Hee Jung Ryu, Mi Ryoung Seo, Hyo Jin Choi, Han Joo Baek
Korean J Intern Med. 2018;33(5):1025-1031. Published online January 12, 2017
Background/Aims: The clinical manifestations of Behcet disease (BD) have been reported to differ according to country, region, and race. Gender, onset age, and human leukocyte antigen (HLA)-B51 have also been known as the factors that influence the clinical features of BD. The aim of this study is t..
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Allergy
Management and educational status of adult anaphylaxis patients at emergency department
Mi-Yeong Kim, Chan Sun Park, Jae-won Jeong
Korean J Intern Med. 2018;33(5):1008-1015. Published online December 28, 2017
Background/Aims: We evaluated the management and educational status of adult anaphylaxis patients at emergency departments (EDs).
Methods: Anaphylaxis patients who visited ED from 2011 to 2013 were enrolled from three hospitals. We analyzed clinical features, prior history of anaphylaxis, managemen..
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Nephrology
Effects of aristolochic acid I and/or hypokalemia on tubular damage in C57BL/6 rat with aristolochic acid nephropathy
Joo-Hark Yi, Sang-Woong Han, Wan-Young Kim, Jin Kim, Moon-Hyang Park
Korean J Intern Med. 2018;33(4):763-773. Published online February 15, 2017
Background/Aims: This study was designed to investigate the roles of aristolochic acid I (AA-I) and hypokalemia in acute aristolochic acid nephropathy (AAN).
Methods: After an adaptation period (1 week), a total of 40 C57BL/6 mice (male, 8 weeks old) were divided into four groups: I (control group)..
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Gastroenterology
Outcomes of patients treated with Sengstaken-Blakemore tube for uncontrolled variceal hemorrhage
Ja Yun Choi, Yun Won Jo, Sang Soo Lee, Wan Soo Kim, Hye Won Oh, Cha Young Kim, Eun Young Yun, Jin Joo Kim, Jae Min Lee, Hong Jun Kim, Hyun Jin Kim, Tae Hyo Kim, Woon Tae Jung, Ok Jae Lee, Rock Bum Kim
Korean J Intern Med. 2018;33(4):696-704. Published online November 10, 2017
Background/Aims: The aim of this study was to investigate the mortality, bleeding control rate, and their associated predictors in patients treated with Sengstaken-Blakemore (SB) tube for uncontrolled variceal hemorrhage associated with hemodynamic instability or failure of endoscopic treatment.
Me..
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Nephrology
Hepatitis C virus infection in chronic kidney disease: paradigm shift in management
So Mi Kim, Il Han Song
Korean J Intern Med. 2018;33(4):670-678. Published online June 28, 2018
Hepatitis C virus (HCV) infection in chronic kidney disease (CKD) is associated with increased liver-related morbidity and mortality rates, accelerated progression to end-stage renal disease, and risk of cardiovascular events. CKD patients with HCV infection require antiviral therapy. Pegylated inte..
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Infectious diseases
Late diagnosis of influenza in adult patients during a seasonal outbreak
Seong-Ho Choi, Jin-Won Chung, Tark Kim, Ki-Ho Park, Mi Suk Lee, Yee Gyung Kwak
Korean J Intern Med. 2018;33(2):391-396. Published online November 10, 2017
Background/Aims: Due to advances in diagnostic techniques, clinicians are more frequently performing influenza diagnostic tests and referring to their test results ahead of the administration of neuraminidase inhibitors (NAIs). To investigate the clinical significance of the time from symptom onset ..
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Gastroenterology
Analysis of computed tomographic findings according to gastroesophageal flap valve grade
Hye Kyung Jeon, Gwang Ha Kim, Nam Kyung Lee, Suk Kim, Bong Eun Lee, Geun Am Song
Korean J Intern Med. 2018;33(2):295-303. Published online December 12, 2016
Background/Aims: The gastroesophageal junction is an important barrier against gastroesophageal ref lux. Endoscopic grading of gastroesophageal f lap valve is simple, reproducible, and may predict reflux activity. We investigated the correlation between gastroesophageal flap valve grade and the gast..
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Rheumatology
An overview of meta-analysis for clinicians
Young Ho Lee
Korean J Intern Med. 2018;33(2):277-283. Published online December 28, 2017
The number of medical studies being published is increasing exponentially, and clinicians must routinely process large amounts of new information. Moreover, the results of individual studies are often insufficient to provide confident answers, as their results are not consistently reproducible. A me..
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Medication nonadherence in Korean patients with rheumatoid arthritis: the importance of belief
about medication and illness perception
Young Sun Suh, Yun-Hong Cheon, Hyun-Ok Kim, Rock-Bum Kim, Ki Soo Park, Sang-Hyon Kim, Seung-Geun Lee, Eun-Kyoung Park, Jian Hur, Sang-Il Lee
Korean J Intern Med. 2018;33(1):203-210. Published online April 20, 2017
Background/Aims: To investigate medication nonadherence in Korean patients with rheumatoid arthritis (RA) and analyze related factors.
Methods: A total of 292 patients with RA participated in this study. Medication nonadherence, intentional or unintentional, was gauged via self-reported questionnai..
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Pulmonology
Factors associated with low-level physical activity in elderly patients with chronic obstructive pulmonary disease
Sang Hee Lee, Ki Uk Kim, Haejung Lee, Yun Seong Kim, Min Ki Lee, Hye-Kyung Park
Korean J Intern Med. 2018;33(1):130-137. Published online June 7, 2017
Background/Aims: In patients with chronic obstructive pulmonary disease (COPD), the extent of physical activity (PA) is correlated with disease severity and prognosis. However, factors associated with low-level PA in elderly COPD patients are not known. We assessed the levels of PA and clinical fact..
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Gastroenterology
Present status and perspectives of endosonography 2017 in gastroenterology
Michael Hocke, Barbara Braden, Christian Jenssen, Christoph F. Dietrich
Korean J Intern Med. 2018;33(1):36-63. Published online November 23, 2017
Endoscopic ultrasound has become an essential tool in modern gastroenterology and abdominal surgery. Compared with all other endoscopic methods, it has the most potential for innovation and its future looks bright. Thus, we compiled this summary of established and novel applications of endoscopic ul..
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Novel treatments for inflammatory bowel disease
Hyo Sun Lee, Soo-Kyung Park, Dong Il Park
Korean J Intern Med. 2018;33(1):20-27. Published online December 11, 2017
Increased understanding of the immunopathology of inflammatory bowel disease (IBD) has led to the development of targeted therapies and has unlocked a new era in IBD treatment. The development of treatment options aimed at a variety of pathological mechanisms offers new hope for customized therapies..
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